Age-associated sex and asymmetry differentiation in hemispheric and lobar cortical ribbon complexity across adulthood : A UK BioBank Imaging Study

Acknowledgements This research has been conducted using the UK Biobank resource. This work was supported by the Aberdeen Biomedical Imaging Centre with financial support from the Roland Sutton Academic Trust (RSAT-0067/R/19). The authors would like to thank the participants of the UK Biobank imaging study and our colleague Dr Naif Majrashi for performing image pre-processing using FreesurferPeer reviewedPublisher PD

Sexual dimorphism in the relationship between brain complexity, volume and general intelligence (g): a cross-cohort study

Changes in brain morphology have been reported during development, ageing and in relation to different pathologies. Brain morphology described by the shape complexity of gyri and sulci can be captured and quantified using fractal dimension (FD). This measure of brain structural complexity, as well as brain volume, are associated with intelligence, but less is known about the sexual dimorphism of these relationships. In this paper, sex differences in the relationship between brain structural complexity and general intelligence (g) in two diverse geographic and cultural populations (UK and Indian) are investigated. 3D T1-weighted magnetic resonance imaging (MRI) data and a battery of cognitive tests were acquired from participants belonging to three different cohorts: Mysore Parthenon Cohort (MPC); Aberdeen Children of the 1950s (ACONF) and UK Biobank. We computed MRI derived structural brain complexity and g estimated from a battery of cognitive tests for each group. Brain complexity and volume were both positively corelated with intelligence, with the correlations being significant in women but not always in men. This relationship is seen across populations of differing ages and geographical locations and improves understanding of neurobiological sex-differences